Laminitis & Overfeeding Insulin dysfunction (ID)

We highlighted two papers related to the ID-theme. The first paper from researchers of the Queensland University of Technology (De Laat et al. 2020) reviews the spectrum of potential therapeutic agents for endocrinopathic laminitis, ranging from early experimental compounds to agents nearing registration. These authors highlight that potential new therapies to prevent or treat laminitis may emerge from new therapies for allied conditions in humans.

The second study executed by researchers from Utrecht University addresses the effect of long-term overfeeding of a high-energy diet on glucose tolerance in Shetland pony mares. When healthy non-obese Shetland pony mares were fed a high energy diet, a more efficient glucose metabolism within 5 weeks was observed. However, this was followed by significant hyperinsulinemia and obesity. The hyperinsulinemic status was reversed during a 17-week hay-only feeding regimen but returned rapidly after restarting the high-energy diet, irrespective of body condition.

• M. A. De Laat and M. N. Sillence. 2020. A review of recent developments in the pharmacological prevention and treatment of endocrinopathic laminitis. Ani.Prod.Sci.
2020,60, 2111–2121. Publisher (Open Access)
• N. M. M. d'Fonseca, C. M. E. Gibson, D. A. van Doorn, M. de Ruijter-Villani, T. A. E. Stout and E.Roelfsema. 2020. Effect of long-term overfeeding of a high-energy diet on glucose
tolerancein Shetland pony mares. J.Vet.Intern.Med. 34 (3): 1339-1349. Publisher.

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